About 65 results.

Google Knowledge Graph

AdipoRon

AdipoRon

Chemical compound

INSL4

Protein

  • Desc: Early placenta insulin-like peptide is a protein that in humans is encoded by the INSL4 gene. INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily.
  • Wiki: https://en.wikipedia.org/wiki/INSL4
  • Knowledge graph id: kg:/m/03hg6d_
  • Type: Thing
  • Result Score: 3.20
Rimegepant

Rimegepant

Drug

  • Desc: Rimegepant is an investigational drug candidate for the treatment of migraine. Originally discovered at Bristol-Myers Squibb, it is currently under development by Biohaven Pharmaceuticals.
  • Wiki: https://en.wikipedia.org/wiki/Rimegepant
  • Knowledge graph id: kg:/g/11df0pxmq6
  • Type: Thing
  • Result Score: 3.01
Ubrogepant

Ubrogepant

Drug

Eptinezumab

Drug

  • Desc: Eptinezumab is an experimental drug being developed by Alder Biopharmaceuticals for the treatment of migraine. It is a monoclonal antibody that targets calcitonin gene-related peptides alpha and beta. It is in Phase III clinical trials as of August 2017.
  • Wiki: https://en.wikipedia.org/wiki/Eptinezumab
  • Knowledge graph id: kg:/g/11c1q93f51
  • Type: Thing
  • Result Score: 2.25

Endothelin receptor antagonist

Drug class

  • Desc: An endothelin receptor antagonist is a drug that blocks endothelin receptors. Three main kinds of ERAs exist: selective ETA receptor antagonists, which affect endothelin A receptors. dual antagonists, which affect both endothelin A and B receptors.
  • Wiki: https://en.wikipedia.org/wiki/Endothelin_receptor_antagonist
  • Knowledge graph id: kg:/m/073rpw
  • Type: Thing
  • Result Score: 2.08

Adipotide

Drug

  • Desc: Adipotide, a peptidomimetic with sequence CKGGRAKDC-GG-D(KLAKLAK)₂, is an experimental proapoptotic drug that has been shown to cause rapid weight loss in mice and rhesus monkeys.
  • Wiki: https://en.wikipedia.org/wiki/Adipotide
  • Knowledge graph id: kg:/m/0hhrqf5
  • Type: Thing
  • Result Score: 2.00
Thyrotropin receptor

Thyrotropin receptor

Protein

Neurotensin receptor 1

Protein

Insulin glulisine

Medication

  • Desc: Insulin glulisine is a rapid-acting insulin analogue that differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid.
  • Wiki: https://en.wikipedia.org/wiki/Insulin_glulisine
  • Knowledge graph id: kg:/m/02pr6x4
  • Type: Thing
  • Result Score: 1.89
FSHB

FSHB

Protein

  • Desc: Follitropin subunit beta also known as follicle-stimulating hormone beta subunit is a protein that in humans is encoded by the FSHB gene. Alternative splicing results in two transcript variants encoding the same protein.
  • Wiki: https://en.wikipedia.org/wiki/FSHB
  • Knowledge graph id: kg:/m/03gwstl
  • Type: Thing
  • Result Score: 1.67

Adiponectin receptor 1

Protein

Mecasermin

Drug

  • Desc: Mecasermin, also known as recombinant human insulin-like growth factor-1, is recombinant form of human insulin-like growth factor 1 which is used for the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome.
  • Wiki: https://en.wikipedia.org/wiki/Mecasermin
  • Knowledge graph id: kg:/m/0412fh1
  • Type: Thing
  • Result Score: 1.62
Levocabastine

Levocabastine

Drug

  • Desc: Levocabastine is a selective second-generation H₁ receptor antagonists which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis.
  • Wiki: https://en.wikipedia.org/wiki/Levocabastine
  • Knowledge graph id: kg:/m/087vby
  • Type: Thing
  • Result Score: 1.61

Glucagon receptor

Protein

  • Desc: The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gₛ and to a lesser extent G alpha q.
  • Wiki: https://en.wikipedia.org/wiki/Glucagon_receptor
  • Knowledge graph id: kg:/m/0f7s1x
  • Type: Thing
  • Result Score: 1.60

Sauvagine

Protein

  • Desc: Sauvagine is a protein that functions as a neuropeptide. It is 40 amino acids in length, and has sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue.
  • Wiki: https://en.wikipedia.org/wiki/Sauvagine
  • Knowledge graph id: kg:/m/012hcn00
  • Type: Thing
  • Result Score: 1.59
GW-803430

GW-803430

Drug

  • Desc: GW-803430 is a drug used in scientific research and is a selective non-peptide antagonist at the melanin concentrating hormone receptor MCH₁. In animal studies it has anxiolytic, antidepressant and anorectic effects.
  • Wiki: https://en.wikipedia.org/wiki/GW-803430
  • Knowledge graph id: kg:/m/06w8v3z
  • Type: Thing
  • Result Score: 1.59
SB-649,868

SB-649,868

Drug

Signaling peptide receptor

Protein

  • Desc: A signaling peptide/protein receptor is a type of receptor which binds one or more signaling peptides or signaling proteins. An example is the tropomyosin receptor kinase B, which is bound and activated by the neurotrophic protein brain-derived neurotrophic factor.
  • Wiki: https://en.wikipedia.org/wiki/Signaling_peptide_receptor
  • Knowledge graph id: kg:/g/11clgm0mn4
  • Type: Thing
  • Result Score: 1.54
Ubenimex

Ubenimex

Chemical compound

  • Desc: Ubenimex, also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase, leukotriene A₄ hydrolase, alanyl aminopeptidase, leucyl/cystinyl aminopeptidase, and membrane dipeptidase.
  • Wiki: https://en.wikipedia.org/wiki/Ubenimex
  • Knowledge graph id: kg:/m/09gc6hs
  • Type: Thing
  • Result Score: 1.52

Calcitonin gene-related peptide receptor antagonist

Class of drugs

Erenumab

Medication

  • Desc: Erenumab is a medication which targets the calcitonin gene-related peptide receptor for the prevention of migraine. It was the first of the group of CGRPR antagonists to be approved in 2018.
  • Wiki: https://en.wikipedia.org/wiki/Erenumab
  • Knowledge graph id: kg:/g/11c0rtwy13
  • Type: Thing
  • Result Score: 1.49
Meclinertant

Meclinertant

Drug

  • Desc: Meclinertant is a drug which acts as a selective, non-peptide antagonist at the neurotensin receptor NTS₁, and was the first non-peptide antagonist developed for this receptor.
  • Wiki: https://en.wikipedia.org/wiki/Meclinertant
  • Knowledge graph id: kg:/m/06w46ht
  • Type: Thing
  • Result Score: 1.49

Glucagon-like peptide-1 receptor agonist

Class of drugs

KiSS1-derived peptide receptor

Protein

  • Desc: The KiSS1-derived peptide receptor is a G protein-coupled receptor which binds the peptide hormone kisspeptin. Kisspeptin is encoded by the metastasis suppressor gene KISS1, which is expressed in a variety of endocrine and gonadal tissues.
  • Wiki: https://en.wikipedia.org/wiki/KiSS1-derived_peptide_receptor
  • Knowledge graph id: kg:/m/03crsl3
  • Type: Thing
  • Result Score: 1.45

Adiponectin receptor 2

Protein

Sacubitril

Sacubitril

Drug

  • Desc: Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug sacubitril/valsartan, known during trials as LCZ696 and marketed under the brand name Entresto, is a treatment for heart failure.
  • Wiki: https://en.wikipedia.org/wiki/Sacubitril
  • Knowledge graph id: kg:/m/011snj1c
  • Type: Thing
  • Result Score: 1.43
THIQ

THIQ

Drug

  • Desc: THIQ is a drug used in scientific research, which is the first non-peptide agonist developed that is selective for the melanocortin receptor subtype MC₄.
  • Wiki: https://en.wikipedia.org/wiki/THIQ
  • Knowledge graph id: kg:/m/06w7s72
  • Type: Thing
  • Result Score: 1.37

Glucagon-like peptide 2 receptor

Protein

SHA-68

SHA-68

Drug

  • Desc: SHA-68 is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR. In animal studies it has anxiogenic effects, and blocks the stimulant action of neuropeptide S.
  • Wiki: https://en.wikipedia.org/wiki/SHA-68
  • Knowledge graph id: kg:/m/06w9nxr
  • Type: Thing
  • Result Score: 1.32

Semaglutide

Pharmaceutical drug

Dulaglutide

Drug

  • Desc: Dulaglutide is a glucagon-like peptide 1 receptor agonist consisting of GLP-1 covalently linked to an Fc fragment of human IgG4. It is used for the treatment of type 2 diabetes and can be used once weekly. GLP-1 is a hormone that is involved in the normalization of level of glucose in blood. The FDA approved dulaglutide for use in the United States in September 2014. The drug is manufactured by Eli Lilly under the brand name Trulicity.
  • Wiki: https://en.wikipedia.org/wiki/Dulaglutide
  • Knowledge graph id: kg:/m/010gmmk1
  • Type: Thing
  • Result Score: 1.29
Galnon

Galnon

Drug

  • Desc: Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR. It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.
  • Wiki: https://en.wikipedia.org/wiki/Galnon
  • Knowledge graph id: kg:/m/07kd2kw
  • Type: Thing
  • Result Score: 1.29
SB-408124

SB-408124

Drug

  • Desc: SB-408124 is a drug which is a non-peptide antagonist selective for the orexin receptor subtype OX₁, with around 70x selectivity for OX₁ over OX₂ receptors, and improved oral bioavailability compared to the older OX₁ antagonist SB-334867.
  • Wiki: https://en.wikipedia.org/wiki/SB-408124
  • Knowledge graph id: kg:/m/05q7qhr
  • Type: Thing
  • Result Score: 1.27

Hypocretin (orexin) receptor 2

Protein

Nemorexant

Pharmaceutical

  • Desc: Nemorexant is a dual orexin receptor antagonist which was originated by Actelion Pharmaceuticals and is under development by Idorsia Pharmaceuticals for the treatment of insomnia. It acts as a selective dual antagonist of the orexin receptors OX₁ and OX₂.
  • Wiki: https://en.wikipedia.org/wiki/Nemorexant
  • Knowledge graph id: kg:/g/11f6gjcjc4
  • Type: Thing
  • Result Score: 1.24
Lifitegrast

Lifitegrast

Drug

  • Desc: Lifitegrast is an FDA approved drug indicated for the treatment of signs and symptoms of dry eye, a syndrome called keratoconjunctivitis sicca. Lifitegrast reduces inflammation by inhibiting inflammatory cell binding.
  • Wiki: https://en.wikipedia.org/wiki/Lifitegrast
  • Knowledge graph id: kg:/g/11cjnn_cc5
  • Type: Thing
  • Result Score: 1.23
SB-334867

SB-334867

Drug

  • Desc: SB-334867 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX₁, with around 50x selectivity for OX₁ over OX₂ receptors.
  • Wiki: https://en.wikipedia.org/wiki/SB-334867
  • Knowledge graph id: kg:/m/05q6jtj
  • Type: Thing
  • Result Score: 1.22

Endothelin B receptor

Protein

Chaetochromin

Chaetochromin

Drug

  • Desc: Chaetochromin, also known as 4548-G05, is an orally active, small-molecule, selective agonist of the insulin receptor. It has potent and long-lasting antidiabetic activity in vivo in mice.
  • Wiki: https://en.wikipedia.org/wiki/Chaetochromin
  • Knowledge graph id: kg:/g/11dfh48wck
  • Type: Thing
  • Result Score: 1.18
Verucerfont

Verucerfont

Drug

  • Desc: Verucerfont is a drug developed by GlaxoSmithKline which acts as a CRF-1 antagonist. Corticotropin releasing factor, also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress, and activates the two corticotropin-releasing hormone receptors CRH-1 and CRH-2.
  • Wiki: https://en.wikipedia.org/wiki/Verucerfont
  • Knowledge graph id: kg:/m/012hf45p
  • Type: Thing
  • Result Score: 1.17
Darusentan

Darusentan

Chemical compound

  • Desc: Darusentan is an endothelin receptor antagonist. Gilead Colorado, a subsidiary of Gilead Sciences, under license from Abbott Laboratories, is developing darusentan for the potential treatment of uncontrolled hypertension.
  • Wiki: https://en.wikipedia.org/wiki/Darusentan
  • Knowledge graph id: kg:/m/05mqkl4
  • Type: Thing
  • Result Score: 1.16
Galmic

Galmic

Drug

  • Desc: Galmic is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR. It has anticonvulsant, antidepressant and analgesic effects in animal studies, but also inhibits memory functions.
  • Wiki: https://en.wikipedia.org/wiki/Galmic
  • Knowledge graph id: kg:/m/06_wrjk
  • Type: Thing
  • Result Score: 1.15
Ambrisentan

Ambrisentan

Drug

  • Desc: Ambrisentan is a drug indicated for use in the treatment of pulmonary hypertension. The peptide endothelin constricts muscles in blood vessels, increasing blood pressure.
  • Wiki: https://en.wikipedia.org/wiki/Ambrisentan
  • Knowledge graph id: kg:/m/02qg5pf
  • Type: Thing
  • Result Score: 1.14
Devazepide

Devazepide

Drug

  • Desc: Devazepide is benzodiazepine drug, but with quite different actions from most benzodiazepines, lacking affinity for GABAA receptors and instead acting as an CCKA receptor antagonist.
  • Wiki: https://en.wikipedia.org/wiki/Devazepide
  • Knowledge graph id: kg:/m/04zw2zt
  • Type: Thing
  • Result Score: 1.13
SR-142948

SR-142948

Drug

  • Desc: SR-142948 is a drug used in scientific research which is a non-peptide antagonist selective for the neurotensin receptors, although not selective between subtypes.
  • Wiki: https://en.wikipedia.org/wiki/SR-142948
  • Knowledge graph id: kg:/m/05zncbf
  • Type: Thing
  • Result Score: 1.13

Taspoglutide

Pharmaceutical drug

  • Desc: Taspoglutide is a pharmaceutical drug, a glucagon-like peptide-1 agonist, under investigation for treatment of type 2 diabetes being codeveloped by Ipsen and Roche. Two phase II trials reported it was effective and well tolerated.
  • Wiki: https://en.wikipedia.org/wiki/Taspoglutide
  • Knowledge graph id: kg:/m/05c1075
  • Type: Thing
  • Result Score: 1.12
HT-2157

HT-2157

Drug

  • Desc: HT-2157 is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin.
  • Wiki: https://en.wikipedia.org/wiki/HT-2157
  • Knowledge graph id: kg:/m/012hdy1p
  • Type: Thing
  • Result Score: 1.12
Telcagepant

Telcagepant

Drug

  • Desc: Telcagepant is a calcitonin gene-related peptide receptor antagonist which was an investigational drug for the acute treatment and prevention of migraine, developed by Merck & Co..
  • Wiki: https://en.wikipedia.org/wiki/Telcagepant
  • Knowledge graph id: kg:/m/05msb7x
  • Type: Thing
  • Result Score: 1.10
Bosentan

Bosentan

Pharmaceutical

  • Desc: Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary artery hypertension. It is licensed in the United States, the European Union and other countries by Actelion Pharmaceuticals for the management of PAH under the trade name Tracleer.
  • Wiki: https://en.wikipedia.org/wiki/Bosentan
  • Knowledge graph id: kg:/m/08bh5_
  • Type: Thing
  • Result Score: 1.09
Selank

Selank

Drug

  • Desc: Selank is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of human tuftsin.
  • Wiki: https://en.wikipedia.org/wiki/Selank
  • Knowledge graph id: kg:/m/09v2v9l
  • Type: Thing
  • Result Score: 1.09
Lorglumide

Lorglumide

Drug

  • Desc: Lorglumide is a drug which inhibits gastrointestinal motility and reduces gastric secretions, acting as a cholecystokinin antagonist, with fairly high selectivity for the CCKA subtype.
  • Wiki: https://en.wikipedia.org/wiki/Lorglumide
  • Knowledge graph id: kg:/m/04z_8m1
  • Type: Thing
  • Result Score: 1.09

Leptin receptor

Protein

  • Desc: Leptin receptor also known as LEP-R or OB-R is a Type I cytokine receptor, a protein that in humans is encoded by the LEPR gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295. Its location is the cell membrane, and it has extracellular, trans-membrane, and intracellular sections.
  • Wiki: https://en.wikipedia.org/wiki/Leptin_receptor
  • Knowledge graph id: kg:/m/03c_8_4
  • Type: Thing
  • Result Score: 1.07
Phosphoramidon

Phosphoramidon

Chemical compound

  • Desc: Phosphoramidon is a chemical compound derived from cultures of Streptomyces tanashiensis. It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme inhibitor.
  • Wiki: https://en.wikipedia.org/wiki/Phosphoramidon
  • Knowledge graph id: kg:/m/09v9x_x
  • Type: Thing
  • Result Score: 1.06
ATC-0175

ATC-0175

Drug

  • Desc: ATC-0175 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH₁.
  • Wiki: https://en.wikipedia.org/wiki/ATC-0175
  • Knowledge graph id: kg:/m/06w939y
  • Type: Thing
  • Result Score: 1.06
Icatibant

Icatibant

Medication

  • Desc: Icatibant, trade name Firazyr, is medication that has been approved by the European Commission for the symptomatic treatment of acute attacks of hereditary angioedema in adults with C1-esterase-inhibitor deficiency.
  • Wiki: https://en.wikipedia.org/wiki/Icatibant
  • Knowledge graph id: kg:/m/02qyt8p
  • Type: Thing
  • Result Score: 1.06
Parathyroid hormone-related protein

Parathyroid hormone-related protein

Protein

Atrasentan

Atrasentan

Drug

  • Desc: Atrasentan is an experimental drug that is being studied for the treatment of various types of cancer, including non-small cell lung cancer. It is also being investigated as a therapy for diabetic kidney disease. Atrasentan failed a phase 3 trial for prostate cancer in patients unresponsive to hormone therapy. A second trial confirmed this finding. It is an endothelin receptor antagonist selective for subtype A.
  • Wiki: https://en.wikipedia.org/wiki/Atrasentan
  • Knowledge graph id: kg:/m/03d2vrl
  • Type: Thing
  • Result Score: 1.05
Pentagastrin

Pentagastrin

Chemical compound

  • Desc: Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.
  • Wiki: https://en.wikipedia.org/wiki/Pentagastrin
  • Knowledge graph id: kg:/m/045krp
  • Type: Thing
  • Result Score: 1.05

Leupeptin

Chemical compound

  • Desc: Leupeptin, also known as N-acetyl-L-leucyl-L-leucyl-L-argininal, is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases.
  • Wiki: https://en.wikipedia.org/wiki/Leupeptin
  • Knowledge graph id: kg:/m/0fhv82
  • Type: Thing
  • Result Score: 1.04
BIIE-0246

BIIE-0246

Drug

Proglumide

Proglumide

Drug

  • Desc: Proglumide is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes.
  • Wiki: https://en.wikipedia.org/wiki/Proglumide
  • Knowledge graph id: kg:/m/03d2myh
  • Type: Thing
  • Result Score: 1.04
Relaxin

Relaxin

Protein

  • Desc: Relaxin is a protein hormone of about 6000 Da first described in 1926 by Frederick Hisaw. The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like peptides, INSL3, INSL4, INSL5 and INSL6.
  • Wiki: https://en.wikipedia.org/wiki/Relaxin
  • Knowledge graph id: kg:/m/08_8c8
  • Type: Thing
  • Result Score: 1.00
Thyrotropin-releasing hormone

Thyrotropin-releasing hormone

Hormone

  • Desc: Thyrotropin-releasing hormone, also called thyrotropin-releasing factor or thyroliberin, is a releasing hormone, produced by the hypothalamus, that stimulates the release of thyrotropin and prolactin from the anterior pituitary.
  • Wiki: https://en.wikipedia.org/wiki/Thyrotropin-releasing_hormone
  • Knowledge graph id: kg:/m/01948n
  • Type: Thing
  • Result Score: 0.98
Gastrin

Gastrin

Hormone

  • Desc: Gastrin is a peptide hormone that stimulates secretion of gastric acid by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.
  • Wiki: https://en.wikipedia.org/wiki/Gastrin
  • Knowledge graph id: kg:/m/02w3tv
  • Type: Thing
  • Result Score: 0.97

Adiporon

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    This process used 20 ms for its computations It spent 4 ms in system calls .